Metallation of benzylic amines via amine-borane complexes

被引：31

作者：

Ebden, MR

Simpkins, NS

Fox, DNA

机构：

[1] Univ Nottingham, Dept Chem, Nottingham NG7 2RD, England

[2] Pfizer Ltd, Cent Res, Dept Discovery Chem, Sandwich CT13 9NJ, Kent, England

来源：

TETRAHEDRON | 1998年 / 54卷 / 42期

关键词：

D O I：

10.1016/S0040-4020(98)00783-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Formation of borane complexes of N,N-dimeihylbenzylamine, N,N-dimethyl(1-naphthyl)methylamine, N,N-dimethyl(2-naphthyl)methylamine, N -methyltetrahydroisoquinoline and N-methylisoindoline facilitates regioselective metallation of these systems using BuLi, giving intermediate benzylic anions which react with a range of electrophiles to give products in good yield. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：12923 / 12952

页数：30

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