Systems chemistry: Pattern formation in random dynamic combinatorial libraries

被引:62
作者
Corbett, Peter T. [1 ]
Sanders, Jeremy K. M. [1 ]
Otto, Sijbren [1 ]
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
关键词
combinatorial chemistry; host-guest systems; molecular recognition; supramolecular chemistry; systems chemistry;
D O I
10.1002/anie.200702460
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) Small talk: Molecular recognition events involving a small subset of members of a dynamic combinatorial library (DCL) can affect all other species in the mixture. For example, patterns emerge in a calculated 322-component DCL (see picture), depending on the random distribution of the binding constants. These events provide an intriguing means for transmitting information between molecules. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:8858 / 8861
页数:4
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