Study of stem cell function using microarray experiments

被引：58

作者：

Perez-Iratxeta, C ^{[1
]}

Palidwor, G ^{[1
]}

Porter, CJ ^{[1
]}

Sanche, NA ^{[1
]}

Huska, MR ^{[1
]}

Suomela, BP ^{[1
]}

Muro, EM ^{[1
]}

Krzyzanowski, PM ^{[1
]}

Hughes, E ^{[1
]}

Campbell, PA ^{[1
]}

Rudnicki, MA ^{[1
]}

Andrade, MA ^{[1
]}

机构：

[1] Ottawa Hlth Res Inst, Ontario Genom Innovat Ctr, Program Mol Med, Ottawa, ON K1H 8L6, Canada

来源：

FEBS LETTERS | 2005年 / 579卷 / 08期

关键词：

stem cell; genornics; microarray analysis; microarray database;

D O I：

10.1016/j.febslet.2005.02.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA Microarrays are used to simultaneously measure the levels of thousands of mRNAs in a sample. We illustrate here that a collection of such measurements in different cell types and states is a sound source of functional predictions, provided the microarray experiments are analogous and the cell samples are appropriately diverse. We have used this approach to study stem cells, whose identity and mechanisms of control are not well understood, generating Affymetrix microarray data from more than 200 samples, including stem cells and their derivatives, from human and mouse. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1795 / 1801

页数：7

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