Efficiencies of reductive amination reactions on different solid supports

被引：20

作者：

Bui, CT ^{[1
]}

Rasoul, FA ^{[1
]}

Ercole, F ^{[1
]}

Pham, Y ^{[1
]}

Maeji, NJ ^{[1
]}

机构：

[1] Chiron Technol Pty Ltd, Clayton, Vic 3168, Australia

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(98)02085-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rreductive amination on resins derivatized with 5-(4-formyl-3,5-demethoxy-phenoxy)valeric acid linker (Barany linker. 1)(1) has been reported to be less effective than on resin derivatized with its monomethoxv analog (2)(2) due to steric hindrance of the extra methoxy functional group within the molecule.(3) A study of these linkers indicate that the origins of such data is also related to the spacer and solid support used in the slurry. Depending on the linker. spacer and solid phase, yields from 10% to 75% were obtained under exactly the same reaction conditions. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9279 / 9282

页数：4

共 14 条

[1] PREPARATION AND APPLICATION OF THE 5-(4-(9-FLUORENYLMETHYLOXYCARBONYL)AMINOMETHYL-3,5-DIMETHOXYPHENOXY)VALERIC ACID (PAL) HANDLE FOR THE SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE AMIDES UNDER MILD CONDITIONS [J].