Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions

被引：739

作者：

Ning, Xinghai ^{[1
]}

Guo, Jun ^{[1
]}

Wolfert, Margreet A. ^{[1
]}

Boons, Geert-Jan ^{[1
]}

机构：

[1] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 12期

关键词：

azides; carbohydrates; click chemistry; glycoconjugates;

D O I：

10.1002/anie.200705456

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Presented) CuI-free click: 4-Dibenzocyclooctynol reacts, in the absence of a CuI catalyst, exceptionally fast with azido-containing saccharides and amino acids to give stable triazoles. A biotin-modified derivative is ideally suited for visualizing and tracking glycoconjugates of living cells that are metabolically labeled with azido-containing monosaccharides (see image). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2253 / 2255

页数：3

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