Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1β

被引：90

作者：

Kruse, M

Meinl, E

Henning, G

Kuhnt, C

Berchtold, S

Berger, T

Schuler, G

Steinkasserer, A

机构：

[1] Univ Erlangen Nurnberg, Dept Dermatol, D-91052 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Inst Clin & Mol Virol, D-91052 Erlangen, Germany

[3] Max Planck Inst Neurobiol, Dept Neuroimmunol, Martinsried, Germany

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 167卷 / 04期

关键词：

D O I：

10.4049/jimmunol.167.4.1989

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Signaling lymphocyte activation molecule (SLAM), a 70-kDa costimulatory molecule that mediates CD28-independent proliferation of T cells and IFN-gamma production, has been identified on human T cells, immature thymocytes, and a subset of B cells. We have found that SLAM is expressed on mature but not immature dendritic cells (DQ. However, the SLAM-associated protein, is missing in DC. SLAM surface expression is strongly up-regulated by IL-1 beta. Addition of IL-1 beta to the DC maturation mixture also increases the stimulatory properties of DC. These findings provide a new marker for DC maturation and help to explain two areas of DC biology. First, SLAM is a receptor for the measles virus, previously shown to infect DC. Second, SLAM could possibly contribute to the enhanced immunostimulatory functions of DC that are observed following the addition of IL-1. The Journal of Immunology, 2001.

引用

页码：1989 / 1995

页数：7

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