Increase of total homocysteine concentration in cerebrospinal fluid in patients with Alzheimer's disease and Parkinson's disease

被引：107

作者：

Isobe, C ^{[1
]}

Murata, T ^{[1
]}

Sato, C ^{[1
]}

Terayama, Y ^{[1
]}

机构：

[1] Iwate Med Univ, Dept Neurol, Morioka, Iwate 0208505, Japan

来源：

LIFE SCIENCES | 2005年 / 77卷 / 15期

关键词：

Alzheimer's disease; Parkinson's disease; free bomocysteine; total homocysteme; cerebrospinal fluid;

D O I：

10.1016/j.lfs.2005.02.014

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We determined the concentrations of free homocysteine (HC) and total HC in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) or Parkinson's disease (PD) in order to elucidate whether HC is related to the pathogenesis of these neurodegenerative diseases. The concentration of free HC did not differ significantly from that of the normal controls, while the concentration of total HC was significantly higher in the AD and PD patients (+31% in AD,+31% in PD; p < 0.05). These findings suggest that an increase of total HC concentration in the brain is commonly seen in patients with AD and PD, and this may be related to the pathogenesis of these two diseases. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1836 / 1843

页数：8

共 25 条

[11] Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease [J].

Kruman, II ;

Kumaravel, TS ;

Lohani, A ;

Pedersen, WA ;

Cutler, RG ;

Kruman, Y ;

Haughey, N ;

Lee, J ;

Evans, M ;

Mattson, MP .

JOURNAL OF NEUROSCIENCE, 2002, 22 (05) :1752-1762

[12] Hyperhomocysteinaemia in Parkinson's disease [J].

Kuhn, W ;

Roebroek, R ;

Blom, H ;

van Oppenraaij, D ;

Muller, T .

JOURNAL OF NEUROLOGY, 1998, 245 (12) :811-812

[13] Identification of cognitive impairment in the elderly: Homocysteine is an early marker [J].

Lehmann, M ;

Gottfries, CG ;

Regland, B .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 1999, 10 (01) :12-20

[14]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[15] Nigral endothelial dysfunction, homocysteine, and Parkinson's disease [J].

Müller, T ;

Werne, B ;

Fowler, B ;

Kuhn, W .

LANCET, 1999, 354 (9173) :126-127

[16] HOMOCYSTEINE, A THROMBOGENIC AGENT, SUPPRESSES ANTICOAGULANT HEPARAN-SULFATE EXPRESSION IN CULTURED PORCINE AORTIC ENDOTHELIAL-CELLS [J].

NISHINAGA, M ;

OZAWA, T ;

SHIMADA, K .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (03) :1381-1386

[17] Role of homocysteine in age-related vascular and non-vascular diseases [J].

Parnetti, L ;

Bottiglieri, T ;

Lowenthal, D .

AGING-CLINICAL AND EXPERIMENTAL RESEARCH, 1997, 9 (04) :241-257

[18]

RATAN RR, 1994, J NEUROCHEM, V62, P376

[19]

RATAN RR, 1994, J NEUROSCI, V14, P4385

[20] VITAMIN STATUS AND INTAKE AS PRIMARY DETERMINANTS OF HOMOCYSTEINEMIA IN AN ELDERLY POPULATION [J].

SELHUB, J ;

JACQUES, PF ;

WILSON, PWF ;

RUSH, D ;

ROSENBERG, IH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (22) :2693-2698

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