Mitochondrial fission in apoptosis

被引:639
作者
Youle, RJ [1 ]
Karbowski, M [1 ]
机构
[1] Natl Inst Neurol Disorders & Stroke, Biochem Sect, Surg Neurol Branch, Natl Inst Hlth, Bethesda, MD 20892 USA
关键词
D O I
10.1038/nrm1697
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Mitochondria fuse and divide continuously within cells to form a dynamic network. One of the steps in apoptosis is the fragmentation of mitochondria, and recent evidence indicates that the mitochondrial fission machinery actively participates in the process of programmed cell death.
引用
收藏
页码:657 / 663
页数:7
相关论文
共 73 条
  • [41] Mitochondrial fusion intermediates revealed in vitro
    Meeusen, S
    McCaffery, JM
    Nunnari, J
    [J]. SCIENCE, 2004, 305 (5691) : 1747 - 1752
  • [42] The inner membrane protein Mdm33 controls mitochondrial morphology in yeast
    Messerschmitt, M
    Jakobs, S
    Vogel, F
    Fritz, S
    Dimmer, KS
    Neupert, W
    Westermann, B
    [J]. JOURNAL OF CELL BIOLOGY, 2003, 160 (04) : 553 - 564
  • [43] Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p
    Mozdy, AD
    McCaffery, JM
    Shaw, JM
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 151 (02) : 367 - 379
  • [44] Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death
    Mukamel, Z
    Kimchi, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (35) : 36732 - 36738
  • [45] Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis
    Nechushtan, A
    Smith, CL
    Lamensdorf, I
    Yoon, SH
    Youle, RJ
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 153 (06) : 1265 - 1276
  • [46] Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein
    Nemoto, Y
    De Camilli, P
    [J]. EMBO JOURNAL, 1999, 18 (11) : 2991 - 3006
  • [47] Dynamic recruitment of dynamin for final mitochondrial severance in a primitive red alga
    Nishida, K
    Takahara, M
    Miyagishima, S
    Kuroiwa, H
    Matsuzaki, M
    Kuroiwa, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) : 2146 - 2151
  • [48] Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
    Olichon, A
    Baricault, L
    Gas, N
    Guillou, E
    Valette, A
    Belenguer, P
    Lenaers, G
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) : 7743 - 7746
  • [49] The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space
    Olichon, A
    Emorine, LJ
    Descoins, E
    Pelloquin, L
    Brichese, L
    Gas, N
    Guillou, E
    Delettre, C
    Valette, A
    Hamel, CP
    Ducommun, B
    Lenaers, G
    Belenguer, P
    [J]. FEBS LETTERS, 2002, 523 (1-3) : 171 - 176
  • [50] The division of endosymbiotic organelles
    Osteryoung, KW
    Nunnari, J
    [J]. SCIENCE, 2003, 302 (5651) : 1698 - 1704