Cell-mediated drug delivery

被引：262

作者：

Batrakova, Elena V. ^{[1
]}

Gendelman, Howard E. ^{[1
,2
,3
]}

Kabanov, Alexander V. ^{[1
,3
,4
]}

机构：

[1] Univ Nebraska Med Ctr, Ctr Drug Delivery & Nanomed, Dept Pharmaceut Sci, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Ctr Neurodegenerat Disorders, Omaha, NE 68198 USA

[3] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA

[4] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

来源：

EXPERT OPINION ON DRUG DELIVERY | 2011年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

MESENCHYMAL STEM-CELLS; BLOOD-BRAIN-BARRIER; MARROW STROMAL CELLS; POLYION COMPLEX MICELLES; CHARGED BLOCK-COPOLYMERS; RAT GLIOMA MODEL; PARKINSONS-DISEASE; MACROPHAGE DELIVERY; NEUROTROPHIC FACTOR; SURFACE-CHARGE;

D O I：

10.1517/17425247.2011.559457

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered: This paper reviews how immunocytes laden with drugs can cross the blood--brain or blood--tumor barriers to facilitate treatments for infectious diseases, injury, cancer, or inflammatory diseases. The promises and perils of cell-mediated drug delivery are reviewed, with examples of how immunocytes can be harnessed to improve therapeutic end points. Expert opinion: Using cells as delivery vehicles enables targeted drug transport and prolonged circulation times, along with reductions in cell and tissue toxicities. Such systems for drug carriage and targeted release represent a new disease-combating strategy being applied to a spectrum of human disorders. The design of nanocarriers for cell-mediated drug delivery may differ from those used for conventional drug delivery systems; nevertheless, engaging different defense mechanisms in drug delivery may open new perspectives for the active delivery of drugs.

引用

页码：415 / 433

页数：19

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