The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma

被引：55

作者：

Brouwer, R ^{[1
]}

Pruijn, GJM ^{[1
]}

van Venrooij, WJ ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Biochem, NL-6500 HB Nijmegen, Netherlands

来源：

ARTHRITIS RESEARCH | 2001年 / 3卷 / 02期

关键词：

autoantibodies; autoantigens; exoribonucleases; exosome; PM/Scl complex;

D O I：

10.1186/ar147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3'-->5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.

引用

页码：102 / 106

页数：5

共 51 条

[1] MOLECULAR CHARACTERIZATION OF AN AUTOANTIGEN OF PM-SCL IN THE POLYMYOSITIS SCLERODERMA OVERLAP SYNDROME - A UNIQUE AND COMPLETE HUMAN CDNA-ENCODING AN APPARENT 75-KD ACIDIC PROTEIN OF THE NUCLEOLAR COMPLEX [J].

ALDERUCCIO, F ;

CHAN, EKL ;

TAN, EM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (04) :941-952

[2] The yeast exosome and human PM-Scl are related complexes of 3′→5′ exonucleases [J].

Allmang, C ;

Petfalski, E ;

Podtelejnikov, A ;

Mann, M ;

Tollervey, D ;

Mitchell, P .

GENES & DEVELOPMENT, 1999, 13 (16) :2148-2158

[3] Functions of the exosome in rRNA, snoRNA and snRNA synthesis [J].

Allmang, C ;

Kufel, J ;

Chanfreau, G ;

Mitchell, P ;

Petfalski, E ;

Tollervey, D .

EMBO JOURNAL, 1999, 18 (19) :5399-5410

[4] Degradation of ribosomal RNA precursors by the exosome [J].

Allmang, Christine ;

Mitchell, Philip ;

Petfalski, Elisabeth ;

Tollervey, David .

NUCLEIC ACIDS RESEARCH, 2000, 28 (08) :1684-1691

[5] The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex [J].

Anderson, JSJ ;

Parker, R .

EMBO JOURNAL, 1998, 17 (05) :1497-1506

[6] Interrelationship of major histocompatibility complex class II alleles and autoantibodies in four ethnic groups with various forms of myositis [J].

Arnett, FC ;

Targoff, IN ;

Mimori, T ;

Goldstein, R ;

Warner, NB ;

Reveille, JD .

ARTHRITIS AND RHEUMATISM, 1996, 39 (09) :1507-1518

[7]

Baker RE, 1998, GENETICS, V149, P73

[8]

BAUTZ FA, 1994, MANUAL BIOL MARKERS

[9] Identification of an α-helical epitope region on the PM/Scl-100 autoantigen with structural homology to a region on the heterochromatin p25β autoantigen using immobilized overlapping synthetic peptides [J].

Blüthner, M ;

Mahler, M ;

Müller, DB ;

Dünzl, H ;

Bautz, FA .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2000, 78 (01) :47-54

[10] CLONING AND CHARACTERIZATION OF THE CDNA CODING FOR A POLYMYOSITIS-SCLERODERMA OVERLAP SYNDROME RELATED NUCLEOLAR 100-KD PROTEIN [J].

BLUTHNER, M ;

BAUTZ, FA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) :973-980

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