How does HTLV-I persist despite a strong cell-mediated immune response?

被引:46
作者
Asquith, Becca [1 ]
Bangharn, Charles R. M. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Immunol, Wright Fleming Inst, London W2 1PG, England
基金
英国医学研究理事会;
关键词
D O I
10.1016/j.it.2007.09.006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that infects human CD4(+) T lymphocytes. Despite its presence in T cells, HTLV-1 causes little overt immunosuppression. This host-virus relationship has therefore been exploited as an excellent model system for studying the dynamic interaction between a persistent retrovirus and the normal human immune system. We use a combination of mathematical and experimental techniques to identify key factors on both sides of the in vivo host-virus interaction that significantly determine HTLV-1 proviral load and disease risk. We develop a model to describe how these factors interact to enable viral persistence.
引用
收藏
页码:4 / 11
页数:8
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