Magnolol and honokiol: Inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors

被引：31

作者：

Han, Sang Jun ^{[1
]}

Bae, Eun-Ah ^{[1
]}

Trinh, Hien Trung ^{[1
]}

Yang, Jung-Hwa ^{[1
]}

Youn, Ui-Jung ^{[2
]}

Bae, Ki-Hwan ^{[2
]}

Kim, Dong-Hyun ^{[1
]}

机构：

[1] Kyung Hee Univ, Dept Pharmaceut Sci, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2007年 / 30卷 / 11期

关键词：

magnolol; honokiol; itching; passive cutaneous anaphylaxis reaction; allergy;

D O I：

10.1248/bpb.30.2201

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antiallergic effects of magnolol and honokiol, isolated from the bark of Magnolia obovata (family Magnoliaceae), were investigated both in vitro and in vivo. Magnolol and honokiol potently inhibited passive cutaneous anaphylaxis reactions in mice induced by IgE-antigen complex as well as compound 48/80-induced scratching behaviors. These constituents exhibited not only potent inhibitory activity on the degranulation of RBL-2H3 cells induced by IgE-antigen complex, with IC50 values of 45 and 55 mu M, respectively, but also inhibited the protein expressions of IL-4 and TNF-alpha. Based on these findings, magnolol and honokiol may improve IgE-induced allergic diseases.

引用

页码：2201 / 2203

页数：3

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