Surfing pathogens and the lessons learned for actin polymerization

被引:166
作者
Frishknecht, F [1 ]
Way, M [1 ]
机构
[1] European Mol Biol Lab, Cell Biol & Biophys Programme, D-69117 Heidelberg, Germany
关键词
D O I
10.1016/S0962-8924(00)01871-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A number of unrelated bacterial species as well as vaccinia virus (ab)use the process of actin polymerization to facilitate and enhance their infection cycle. Studies into the mechanism by which these pathogens hijack and control the actin cytoskeleton have provided many interesting insights into the regulation of actin polymerization in migrating cells. This review focuses on what we have learnt from the actin-based motilities of Listeria, Shigella and vaccinia and discusses what we would still like to learn from our nasty friends, including enteropathogenic Escherichia coli and Rickettsia.
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页码:30 / 38
页数:9
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