Surfing pathogens and the lessons learned for actin polymerization

被引:166
作者
Frishknecht, F [1 ]
Way, M [1 ]
机构
[1] European Mol Biol Lab, Cell Biol & Biophys Programme, D-69117 Heidelberg, Germany
关键词
D O I
10.1016/S0962-8924(00)01871-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A number of unrelated bacterial species as well as vaccinia virus (ab)use the process of actin polymerization to facilitate and enhance their infection cycle. Studies into the mechanism by which these pathogens hijack and control the actin cytoskeleton have provided many interesting insights into the regulation of actin polymerization in migrating cells. This review focuses on what we have learnt from the actin-based motilities of Listeria, Shigella and vaccinia and discusses what we would still like to learn from our nasty friends, including enteropathogenic Escherichia coli and Rickettsia.
引用
收藏
页码:30 / 38
页数:9
相关论文
共 103 条
[81]  
SCHAFER DA, TRAFFIC
[82]   Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and Listeria monocytogenes motility [J].
Skoble, J ;
Portnoy, DA ;
Welch, MD .
JOURNAL OF CELL BIOLOGY, 2000, 150 (03) :527-537
[83]   The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin [J].
Smith, GA ;
Theriot, JA ;
Portnoy, DA .
JOURNAL OF CELL BIOLOGY, 1996, 135 (03) :647-660
[84]  
Southwick FS, 2000, CELL MOTIL CYTOSKEL, V45, P272, DOI 10.1002/(SICI)1097-0169(200004)45:4<272::AID-CM3>3.3.CO
[85]  
2-5
[86]   Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells [J].
Suzuki, T ;
Mimuro, H ;
Miki, H ;
Takenawa, T ;
Sasaki, T ;
Nakanishi, H ;
Takai, Y ;
Sasakawa, C .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (11) :1905-1920
[87]   Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility [J].
Suzuki, T ;
Saga, S ;
Sasakawa, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (36) :21878-21885
[88]   Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri [J].
Suzuki, T ;
Miki, H ;
Takenawa, T ;
Sasakawa, C .
EMBO JOURNAL, 1998, 17 (10) :2767-2776
[89]   Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP [J].
Taunton, J ;
Rowning, BA ;
Coughlin, ML ;
Wu, M ;
Moon, RT ;
Mitchison, TJ ;
Larabell, CA .
JOURNAL OF CELL BIOLOGY, 2000, 148 (03) :519-530
[90]   INTRACELLULAR MOVEMENTS OF RICKETTSIA-CONORII AND R-TYPHI BASED ON ACTIN POLYMERIZATION [J].
TEYSSEIRE, N ;
CHICHEPORTICHE, C ;
RAOULT, D .
RESEARCH IN MICROBIOLOGY, 1992, 143 (09) :821-829