The competitive nature of cells

被引：40

作者：

Díaz, B ^{[1
]}

Moreno, E ^{[1
]}

机构：

[1] CNIO, E-28029 Madrid, Spain

来源：

EXPERIMENTAL CELL RESEARCH | 2005年 / 306卷 / 02期

关键词：

Drosophila; cell competition; stem cell;

D O I：

10.1016/j.yexcr.2005.03.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The possibility that cells of multicellular organisms may compete with one another has been postulated several times. It was experimentally confirmed in Drosophila, probably for the first time, when cells with different metabolic rates were mixed: cells that would have been viable on their own disappeared due to the presence of metabolically more active cells. After almost 30 years of neglect, genetic analysis in Drosophila has started to reveal a gene network that regulates the competitive behavior of cells. If the genes regulating cellular competitiveness in Drosophila have a conserved function in mammals, the study of cell competition could have an impact in several biomedical fields, including functional degeneration, cancer, or stem cell therapies. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：317 / 322

页数：6

共 44 条

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