The 245 kb amplified chromosome of Leishmania (V.) braziliensis contains a biopterin transporter gene

被引：4

作者：

Sampaio, MCR

Traub-Cseko, YM

机构：

[1] Univ Estado Rio De Janeiro, Dept Biol Celular & Genet, BR-2055013 Rio De Janeiro, RJ, Brazil

[2] Fiocruz MS, Inst Oswaldo Cruz, Dept Bioquim & Biol Mol, Rio De Janeiro, RJ, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2003年 / 98卷 / 03期

关键词：

Leishmania (V.) braziliensis; small chromosome; genomic amplification;

D O I：

10.1590/S0074-02762003000300014

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Leishmania (V.) braziliensis M2903 presents a small linear and stable 245 kb chromosome originating from a genomic amplification. Similar amplifications present in other species of Leishmania contain a gene coding for a biopterin transporter Since Leishmania is auxotrophic for this metabolite, this amplification could result from the need to better capture biotpterin from growth media under specific circumstances. In this paper we show that this gene is also present in L. (V.) braziliensis small chromosome, which shares sequences with other genomic amplifications already described.

引用

收藏

页码：377 / 378

页数：2

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