Phage display in pharmaceutical biotechnology

被引：210

作者：

Sidhu, SS ^{[1
]}

机构：

[1] Genentech Inc, Dept Prot Engn, San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(00)00152-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past year, methods for the construction of M13 phage-display libraries have been significantly improved and new display formats have been developed. Phage-displayed peptide libraries have been used to isolate specific ligands for numerous protein targets. New phage antibody libraries have further expanded the practical applications of the technology and phage cDNA libraries have proven useful in defining natural binding interactions. In addition, phage-display methods have been developed for the rapid determination of binding energetics at protein-protein interfaces.

引用

页码：610 / 616

页数：7

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