Translational regulation by ABC systems

被引：30

作者：

Chakraburtty, K ^{[1
]}

机构：

[1] Med Coll Wisconsin, Dept Biochem, Milwaukee, WI 53226 USA

来源：

RESEARCH IN MICROBIOLOGY | 2001年 / 152卷 / 3-4期

关键词：

elongation factor 3; ABC protein; ATPase; ribosomal reactions;

D O I：

10.1016/S0923-2508(01)01210-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Elongation factor 3 is a cytosolic protein required by the fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates binding of EF-1:GTP:aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：391 / 399

页数：9

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