Cell cycle: Waiters serving the destruction machinery

被引：54

作者：

Vodermaier, HC ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 20期

关键词：

D O I：

10.1016/S0960-9822(01)00498-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Targeting regulatory proteins for destruction, and thereby controlling progression through mitosis, is the crucial task for the anaphase-promoting complex (APC). Recent evidence suggests that essential APC activators, WD40 repeat proteins of the Cdc20 family, act as long-suspected receptors for APC substrates.

引用

收藏

页码：R834 / R837

页数：4

相关论文

共 26 条

[11] The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases [J].

Jackson, PK ;

Eldridge, AG ;

Freed, E ;

Furstenthal, L ;

Hsu, JY ;

Kaiser, BK ;

Reimann, JDR .

TRENDS IN CELL BIOLOGY, 2000, 10 (10) :429-439

[12] RING finger proteins: Mediators of ubiquitin ligase activity [J].

Joazeiro, CAP ;

Weissman, AM .

CELL, 2000, 102 (05) :549-552

[13] Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family [J].

Kramer, ER ;

Gieffers, C ;

Hölzl, G ;

Hengstschläger, M ;

Peters, JM .

CURRENT BIOLOGY, 1998, 8 (22) :1207-1210

[14] SCF and APC: the Yin and Yang of cell cycle regulated proteolysis [J].

Peters, JM .

CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (06) :759-768

[15]

Pfleger CM, 2000, GENE DEV, V14, P655

[16] Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1 [J].

Pfleger, CM ;

Salic, A ;

Lee, E ;

Kirschner, MW .

GENES & DEVELOPMENT, 2001, 15 (14) :1759-1764

[17] Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex [J].

Pfleger, CM ;

Lee, E ;

Kirschner, MW .

GENES & DEVELOPMENT, 2001, 15 (18) :2396-2407

[18] Cdc28 activates exit from mitosis in budding yeast [J].

Rudner, AD ;

Hardwick, KG ;

Murray, AW .

JOURNAL OF CELL BIOLOGY, 2000, 149 (07) :1361-1376

[19] Yeast Hct1 is a regulator of Clb2 cyclin proteolysis [J].

Schwab, M ;

Lutum, AS ;

Seufert, W .

CELL, 1997, 90 (04) :683-693

[20]

SCHWAB M, 2001, IN PRESS EMBO J