Copper-catalyzed regiospecific synthesis of N-alkylbenzimidazoles

被引：99

作者：

Zheng, Nan ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 23期

关键词：

D O I：

10.1021/ol7020737

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed method is described for the preparation of N-alkylbenzimidazoles in regioisomerically pure form starting from o-haloanilines. The method utilizing CuI and trans-N,N'-dimethyl-1,2-cyclohexanediamine allows the preparation of N-alkylbenzimidazoles in good to excellent yields.

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页码：4749 / 4751

页数：3

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