CSF hypocretin-1 levels in restless legs syndrome

被引：22

作者：

Stiasny-Kolster, K

Mignot, E

Ling, L

Möller, JC

Cassel, W

Oertel, WH

机构：

[1] Univ Marburg, Ctr Nervous Dis, Dept Neurol, D-35033 Marburg, Germany

[2] Univ Marburg, Dept Internal Med, D-35033 Marburg, Germany

[3] Stanford Univ, Dept Psychiat & Behav Sci, Stanford Ctr Narcolepsy Res, Med Ctr, Stanford, CA 94305 USA

来源：

NEUROLOGY | 2003年 / 61卷 / 10期

关键词：

D O I：

10.1212/01.WNL.0000094196.50155.38

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

CSF hypocretin-1 levels at 6 PM did not significantly differ between patients with restless legs syndrome (RLS) and control subjects as measured by direct radioimmunoassay and after acid extraction. The authors did not observe significant differences between early onset and late onset RLS. Hypocretin-1 levels did not correlate with RLS severity or polysomnographic measures. These results contrast with previous findings reporting significantly increased CSF hypocretin-1 in the late evening and mostly in early onset RLS.

引用

页码：1426 / 1429

页数：5

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