Expression, regulation and function of trail in atherosclerosis

被引：60

作者：

Kavurma, Mary M. ^{[1
]}

Bennett, Martin R. ^{[2
]}

机构：

[1] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2052, Australia

[2] Univ Cambridge, Addenbrookes Hosp, Div Cardiovasc Med, Cambridge CB2 2QQ, England

来源：

BIOCHEMICAL PHARMACOLOGY | 2008年 / 75卷 / 07期

关键词：

D O I：

10.1016/j.bcp.2007.10.020

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atherosclerosis is a condition where vascular smooth muscle cells (VSMCs), inflammatory Received cells, lipids, cholesterol and cellular waste accumulate in the inner lining of an artery, producing a fibro-fatty plaque and resulting in the thickening of the arterial wall. The tumor necrosis factor (TNF) family of cytokines plays a major role in the progression of atherosclerosis. Recently, TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily, has been implicated in the development of atherosclerosis since it has been detected in normal and diseased atherosclerotic tissue. Not only is TRAIL involved in apoptosis and immune regulation, recent studies have provided a new function of TRAIL on vascular cells, such that TRAIL can promote endothelial cell (EC) and VSMCs migration and proliferation. In addition, TRAIL is implicated in regulating vascular tone. This review discusses our current understanding of TRAIL expression, regulation and function, and summarises the recent data implicating a role for TRAIL in atherosclerosis. Crown Copyright (c) 2007 Published by Elsevier Inc. All rights reserved.

引用

页码：1441 / 1450

页数：10

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