Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery

被引：93

作者：

Broaders, Kyle E. ^{[1
]}

Pastine, Stefan J. ^{[1
]}

Grandhe, Sirisha ^{[1
]}

Frechet, Jean M. J. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 02期

关键词：

DEXTRAN; MICROPARTICLES; NANOPARTICLES; MINIEMULSION; POLYMER;

D O I：

10.1039/c0cc04190d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.

引用

页码：665 / 667

页数：3

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