The effects of APOE genotype on age at onset and progression of neurodegenerative diseases

被引：54

作者：

Chapman, J

Korczyn, AD

Karussis, DM

Michaelson, DM ^{[1
]}

机构：

[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69789 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Med, Dept Neurol, IL-69978 Tel Aviv, Israel

[4] Hadassah Med Ctr, Dept Neurol, IL-91120 Jerusalem, Israel

来源：

NEUROLOGY | 2001年 / 57卷 / 08期

关键词：

D O I：

10.1212/WNL.57.8.1482

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

APOE genotype influences the age at onset of some neurodegenerative diseases such as AD and the rate of progression in others such as MS. The authors hypothesize that APOE genotype ubiquitously determines the efficacy of neuronal maintenance and repair in these diseases and that the seemingly divergent clinical effects are due to the stage of disease at which the diagnosis is made. Early diagnosis facilitates the measurement of effects on disease progression rate, whereas late diagnosis results in a marked effect of APOE genotype on disease onset.

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页码：1482 / 1485

页数：4

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