The emerging role of adipokines as mediators of cardiovascular function:: Physiologic and clinical perspectives

被引:155
作者
Gualillo, Oreste
Ramon Gonzalez-Juanatey, Jose
Lago, Francisca
机构
[1] Univ Santiago, Hosp & Clin, Lab Neuro Endocrin Interact Rheumatol & Inflammat, Res Lab 4, Santiago De Compostela 15706, Spain
[2] Univ Santiago, Hosp & Clin, Res Lab 1, Div Cardiol, Santiago De Compostela 15706, Spain
关键词
D O I
10.1016/j.tcm.2007.09.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Interest in the biology of white adipose tissue has increased dramatically since the discovery of leptin in 1994. The identification of the product of the gene obese (ob) threw light on the role of adipose tissue in the physiopathology of obesity-related diseases and spurred the identification of numerous other adipokines, many of a proinflammatory nature. It has become increasingly evident that white adipose tissue-derived cytokines mediate between obesity-related exogenous factors (nutrition and lifestyle) and the molecular events that lead to metabolic syndrome, inflammation, and cardiovascular diseases. Here we review recent adipokine research, with particular attention to the roles of adiponectin, leptin, resistin, visfatin, apelin, omentin, and chemerin in such conditions.
引用
收藏
页码:275 / 283
页数:9
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