Sequential injection method for the direct spectrophotometric determination of bismuth in pharmaceutical products

被引:29
作者
Tzanavaras, PD [1 ]
Themelis, DG [1 ]
Economou, A [1 ]
机构
[1] Aristotle Univ Thessaloniki, Dept Chem, Analyt Chem Lab, Thessaloniki 54124, Greece
关键词
bismuth; spectrophotometry; methylthymol blue; sequential injection; pharmaceutical products;
D O I
10.1016/S0003-2670(03)00017-5
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A spectrophotometric method is reported for the determination of bismuth in pharmaceutical products using sequential injection analysis. Methylthymol blue (MTB) was used as a color forming reagent and the absorbance of the Bi(III)-MTB complex was monitored at 548 nm. The various chemical and physical variables that affected the reaction were studied. A linear calibration graph was obtained in the range 0.0-75.0 mg I-1 Bi(III) at a sampling frequency of 72h(-1). The reagent consumption was considerably reduced compared to conventional flow injection systems, as only 150 mul of MTB were consumed per run. The precision was very satisfactory (s(r) = 0.5%, at 50.0 mg I-1 Bi(III), n = 12) and the limit of detection, c(L), Was 0.250 mg I-1. The developed method was applied successfully to the analysis of various pharmaceutical products containing Bi(III). The relative errors e(r), were < 1.5% in all cases and were evaluated by comparison of the obtained results with those found using atomic absorption spectrometry as the reference method. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:167 / 171
页数:5
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