Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging

被引:149
作者
Solanki, Aniruddh [1 ]
Kim, John D. [1 ]
Lee, Ki-Bum [1 ,2 ,3 ]
机构
[1] Rutgers State Univ, Dept Chem & Biol Chem, Piscataway, NJ 08854 USA
[2] Inst Adv Mat Devices & Nanotechnol, Piscataway, NJ 08854 USA
[3] Rutgers State Univ, Rutgers Stem Cell Res Ctr, Piscataway, NJ 08854 USA
关键词
magnetic nanoparticle; quantum dots; regenerative medicine; stem cell imaging;
D O I
10.2217/17435889.3.4.567
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Although stem cells hold great potential for the treatment of many injuries and degenerative diseases, several obstacles must be overcome before their therapeutic application can be realized. These include the development of advanced techniques to understand and control functions of microenvironmental signals and novel methods to track and guide transplanted stem cells. The application of nanotechnology to stem cell biology would be able to address those challenges. This review details the current challenges in regenerative medicine, the current applications of nanoparticles in stem cell biology and further potential of nanotechnology approaches towards regenerative medicine, focusing mainly on magnetic nanoparticle- and quantum dot-based applications in stem cell research.
引用
收藏
页码:567 / 578
页数:12
相关论文
共 64 条
[51]   Finding fluorescent needles in the cardiac haystack: Tracking human mesenchymal stem cells labeled with quantum dots for quantitative in vivo three-dimensional fluorescence analysis [J].
Rosen, Amy B. ;
Kelly, Damon J. ;
Schuldt, Adam J. T. ;
Lu, Jia ;
Potapova, Irina A. ;
Doronin, Sergey V. ;
Robichaud, Kyle J. ;
Robinson, Richard B. ;
Rosen, Michael R. ;
Brink, Peter R. ;
Gaudette, Glenn R. ;
Cohen, Ira S. .
STEM CELLS, 2007, 25 (08) :2128-2138
[52]   Labeling of mesenchymal stem cells by bioconjugated quantum dots [J].
Shah, Lhranti S. ;
Clark, Paul A. ;
Moioli, Eduardo K. ;
Stroscio, Michael A. ;
Mao, Jeremy J. .
NANO LETTERS, 2007, 7 (10) :3071-3079
[53]   Stem cells in epithelial tissues [J].
Slack, JMW .
SCIENCE, 2000, 287 (5457) :1431-1433
[54]   In vivo quantum dot Labeling of mammalian stem and progenitor cells [J].
Slotkin, Jonathan R. ;
Chakrabarti, Lina ;
Dai, Hai Ning ;
Carney, Rosalind S. E. ;
Hirata, Tsutomu ;
Bregman, Barbara S. ;
Gallicano, G. Ian ;
Corbin, Joshua G. ;
Haydar, Tarik F. .
DEVELOPMENTAL DYNAMICS, 2007, 236 (12) :3393-3401
[55]   Embryo-derived stem cells: Of mice and men [J].
Smith, AG .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2001, 17 :435-462
[56]   Migration, fate and in vivo imaging of adult stem cells in the CNS [J].
Sykova, E. ;
Jendelova, P. .
CELL DEATH AND DIFFERENTIATION, 2007, 14 (07) :1336-1342
[57]   MICROCHIMERISM, DENDRITIC CELL PROGENITORS AND TRANSPLANTATION TOLERANCE [J].
THOMSON, AW ;
LU, L ;
MURASE, N ;
DEMETRIS, AJ ;
RAO, AS ;
STARZL, TE .
STEM CELLS, 1995, 13 (06) :622-639
[58]   Superparamagnetic iron oxide nanoparticle probes for molecular imaging [J].
Thorek, DLJ ;
Chen, A ;
Czupryna, J ;
Tsourkas, A .
ANNALS OF BIOMEDICAL ENGINEERING, 2006, 34 (01) :23-38
[59]   Method for reverse transfection using gold colloid as a nano-scaffold [J].
Uchimura, Eiichiro ;
Yamada, Shigeru ;
Uebersax, Lorenz ;
Fujita, Satoshi ;
Miyake, Masato ;
Miyake, Jun .
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2007, 103 (01) :101-103
[60]   Magnetic resonance tracking of nanoparticle labelled neural stem cells in a rat's spinal cord [J].
Wang, F. H. ;
Lee, I. H. ;
Holmstrom, N. ;
Yoshitake, T. ;
Kim, D. K. ;
Muhammed, M. ;
Frisen, J. ;
Olson, L. ;
Spenger, C. ;
Kehr, J. .
NANOTECHNOLOGY, 2006, 17 (08) :1911-1915