Enhancing DNA triplex stability via nucleobase modifications

被引：3

作者：

Ganesh, KN ^{[1
]}

Kumar, V ^{[1
]}

Barawkar, DA ^{[1
]}

Rajeev, KG ^{[1
]}

Rana, VS ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 02期

关键词：

D O I：

10.1351/pac199870020289

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper demonstrates that covalent conjugation of polyamimic ligands to nucleobase C in the third strand enhances DNA tripler stability at physiological pH and that a modified pyrimidine 5-NH2-dU can be accommodated in the central position of a tripler triad The chemical and biophysical basis for the observed stabilities are discussed and the results have significance in designing oligonucleotides for therapeutic applications.

引用

页码：289 / 292

页数：4

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