Gene conversion: mechanisms, evolution and human disease

被引：462

作者：

Chen, Jian-Min ^{[1
]}

Cooper, David N.

Chuzhanova, Nadia

Ferec, Claude

Patrinos, George P.

机构：

[1] INSERM, U613, F-29220 Brest, France

[2] Establissement Francais Sang, F-29220 Brest, France

[3] Erasmus Univ, Ctr Med, Fac Med & Hlth Sci, MGC Dept Cell Biol & Genet, NL-3000 CA Rotterdam, Netherlands

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 10期

关键词：

D O I：

10.1038/nrg2193

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene conversion, one of the two mechanisms of homologous recombination, involves the unidirectional transfer of genetic material from a 'donor' sequence to a highly homologous 'acceptor'. Considerable progress has been made in understanding the molecular mechanisms that underlie gene conversion, its formative role in human genome evolution and its implications for human inherited disease. Here we assess current thinking about how gene conversion occurs, explore the key part it has played in fashioning extant human genes, and carry out a meta-analysis of gene-conversion events that are known to have caused human genetic disease.

引用

页码：762 / 775

页数：14

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