Gender-related disparities in non-small cell lung cancer

被引：27

作者：

Paggi, Marco G. ^{[2
]}

Vona, Rosa

Abbruzzese, Claudia ^{[2
]}

Malorni, Walter ^{[1
,3
]}

机构：

[1] Ist Super Sanita, Dept Therapeut Res & Med Evaluat, Sect Cell Degenerat & Gender Med, I-00161 Rome, Italy

[2] Natl Canc Inst Regina Elena, Dept Dev Therapeut Programs, I-00144 Rome, Italy

[3] Ist San Raffaele Sulmona, Sulmona, AQ, Italy

来源：

CANCER LETTERS | 2010年 / 298卷 / 01期

关键词：

Cancer; Gender; Non-small cell lung cancer; Estrogens; Apoptosis; Autophagy; GROWTH-FACTOR RECEPTOR; PAPILLOMAVIRUS-16; E7; INTERACTS; NEVER-SMOKERS; ESTROGEN-RECEPTOR; BLADDER-CANCER; GENOMIC INSTABILITY; CIGARETTE-SMOKING; MTOR INHIBITORS; EGFR MUTATION; REDOX STATE;

D O I：

10.1016/j.canlet.2010.08.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiological studies clearly outline some disparities in cancer onset, progression as well as prognosis and therapeutic response between sexes. In particular, in lung cancer, the leading cause of cancer death, at least in Western countries, a gender disparity appears now to emerge, especially for non-small cell lung cancer (NSCLC). Such a disparity is apparently due to a variety of mechanisms, ranging from genetic and epigenetic differences to gender-specific lifestyle as well as to behavioral causes and, clearly, to sex hormones activity. Here we briefly recapitulate gender differences in terms of risk factors, histopathological features and pathogenetic mechanisms in NSCLC, and hypothesize that a gender-oriented pharmacology could beneficially impact on innovative therapeutic strategies. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

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