Role of adipose tissue in facial aging

被引：52

作者：

Wollina, Uwe ^{[1
]}

Wetzker, Reinhard ^{[2
,3
]}

Abdel-Naser, Mohamed Badawy ^{[4
]}

Kruglikov, Ilja L. ^{[5
]}

机构：

[1] Acad Teaching Hosp Dresden Friedrichstadt, Dept Dermatol & Allergol, Friedrichstr 41, D-01067 Dresden, Germany

[2] Jena Univ Hosp, Dept Anesthesia & Intens Care Med, Jena, Germany

[3] Jena Univ Hosp, Ctr Sepsis Control & Care, Jena, Germany

[4] Ain Shams Univ Hosp, Dept Dermatol & Venereol, Cairo, Egypt

[5] Wellcomet GmbH, Karlsruhe, Germany

来源：

CLINICAL INTERVENTIONS IN AGING | 2017年 / 12卷

关键词：

facial aging; adipose tissue; preadipocytes; adipocytes; inflammation; beiging; adipocyte-myofibroblast transition; MIDFACIAL FAT COMPARTMENTS; DERMAL ADIPOCYTES; UV-IRRADIATION; SKIN; INFLAMMATION; BROWN; MICE; DIFFERENTIATION; PROGENITORS; MECHANISMS;

D O I：

10.2147/CIA.S151599

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging.

引用

页码：2069 / 2076

页数：8

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