The transcriptional activator HAP4 is a high copy suppressor of an oxa1 yeast mutation

被引：7

作者：

Hlavacek, O ^{[1
]}

Bourens, M ^{[1
]}

Salone, V ^{[1
]}

Lachacinski, N ^{[1
]}

Lemaire, C ^{[1
]}

Dujardin, G ^{[1
]}

机构：

[1] Ctr Genet Mol, F-91198 Gif Sur Yvette, France

来源：

GENE | 2005年 / 354卷

关键词：

mitochondria; respiratory complexes; Saccharomyces cerevisiae; cytochrome oxidase; membrane insertion;

D O I：

10.1016/j.gene.2005.03.016

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Oxa1p is a key component of the machinery for the insertion of membrane proteins in mitochondria, and in the yeast Saccharomyces cerevisiae, the deletion of OXA1 impairs the biogenesis of the three respiratory complexes of dual genetic origin. Oxa1p is formed from three domains located in the intermembrane space, the inner membrane and the mitochondrial matrix. We have isolated a high copy suppressor able to partially compensate for the respiratory deficiency caused by a large deletion of the matrix domain. We show that the suppressor gene corresponds to the nuclear transcriptional activator Hap4p which is known to regulate respiratory functions. (c) 2005 Elsevier B.V All rights reserved.

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收藏

页码：53 / 57

页数：5

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