Copper(II) triflate as a double catalyst for the one-pot click synthesis of 1,4-disubstituted 1,2,3-triazoles from benzylic acetates

被引：38

作者：

Fukuzawa, Shin-ichi ^{[1
]}

Shimizu, Eiji ^{[1
]}

Kikuchi, Satoshi ^{[1
]}

机构：

[1] Chuo Univ, Inst Sci & Engn, Dept Appl Chem, Bunkyo Ku, Tokyo 1128551, Japan

来源：

SYNLETT | 2007年 / 15期

关键词：

triazole; copper(II) triflate; click reaction;

D O I：

10.1055/s-2007-986638

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper(II) triflate doubly catalyzed the substitution of benzylic acetates by TMSN3 and the subsequent 1,3-dipolar addition with an alkyne in one pot. This procedure afforded the preparation of 1,4-disubstituted 1,2,3-triazoles in good yields starting from the easily accessible acetates without isolating an organic azide using a single catalyst.

引用

页码：2436 / 2438

页数：3

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