Copper-catalyzed synthesis of N-sulfonyl-1,2,3-triazoles:: Controlling selectivity

被引：303

作者：

Yoo, Eun Jeong

Ahlquist, Marten

Kim, Seok Hwan

Bae, Imhyuck

Fokin, Valery V. ^{[1
]}

Sharpless, K. Barry

Chang, Sukbok

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, CMDS, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Sch Mol Sci BK21, Taejon 305701, South Korea

[3] Kemitorvet Technical Univ Denmark, Dept Chem, DK-2888 Lyngby, Denmark

[4] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[5] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 10期

关键词：

alkynes; copper; cycloaddition; sulfonyl azides; sulfonyltriazoles;

D O I：

10.1002/anie.200604241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) 4-Substituted 1-(N-sulfonyl)-1,2,3-triazoles are selectively obtained by using the Cu-catalyzed azide-alkyne cycloaddition reaction with sulfonyl azides. Performing the reaction at 0°C in chloroform in the presence of 2,6-lutidine and Cul as the catalyst effectively prevents the ketenimine pathway and provides convenient access to N-sulfonyltriazoles in good to excellent yields. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1730 / 1733

页数：4

共 38 条

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