Sensory roles of neuronal cilia:: Cilia development, morphogenesis, and function in C-elegans

被引:54
作者
Bae, Young-Kyung [1 ,2 ,3 ]
Barr, Maureen M. [1 ,2 ]
机构
[1] Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Waksman Inst Microbiol, Piscataway, NJ 08854 USA
[3] Univ Wisconsin, Genet Lab, Madison, WI 53705 USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷
关键词
sensory; cilia; C; elegans; receptor trafficking; primary cilia; neuron; behavior; autosomal dominant polycystic kidney disease; ciliopathy; review;
D O I
10.2741/3129
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the free-living nematode Caenorhabditis elegans, cilia are found on the dendritic endings of sensory neurons. C. elegans cilia are classified as 'primary' or 'sensory' according to the '9+0' axonemal ultrastructure (nine doublet outer microtubules with no central microtubule pair) and lack of motility, characteristics of '9+2' cilia. The C. elegans ciliated nervous system allows the animal to perceive environmental stimuli and make appropriate developmental, physiological, and behavioral decisions. In vertebrates, the biological significance of primary cilia had been largely neglected. Recent findings have placed primary/sensory cilia in the center of cellular signaling and developmental processes. Studies using genetic model organisms such as C. elegans identified the link between ciliary dysfunction and human ciliopathies. Future studies in the worm will address important basic questions regarding ciliary development, morphogenesis, specialization, and signaling functions.
引用
收藏
页码:5959 / 5974
页数:16
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