Survival of cancer cells is maintained by EGFR independent of its kinase activity

被引：425

作者：

Weihua, Zhang ^{[2
]}

Tsan, Rachel ^{[2
]}

Huang, Wei-Chien ^{[1
]}

Wu, Qiuyu ^{[2
]}

Chiu, Chao-Hua ^{[1
]}

Fidler, Isaiah J. ^{[2
]}

Hung, Mien-Chie ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

CANCER CELL | 2008年 / 13卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2008.03.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).

引用

页码：385 / 393

页数：9

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