A Histone Acetyltransferase Regulates Active DNA Demethylation in Arabidopsis

被引：210

作者：

Qian, Weiqiang ^{[1
,2
,3
]}

Miki, Daisuke ^{[1
,2
]}

Zhang, Heng ^{[1
,2
,3
]}

Liu, Yunhua ^{[3
,4
,5
]}

Zhang, Xi ^{[6
]}

Tang, Kai ^{[3
]}

Kan, Yunchao ^{[7
]}

La, Honggui ^{[1
,2
,3
]}

Li, Xiaojie ^{[8
]}

Li, Shaofang ^{[9
]}

Zhu, Xiaohong ^{[3
]}

Shi, Xiaobing ^{[6
]}

Zhang, Kangling ^{[10
]}

Pontes, Olga ^{[11
]}

Chen, Xuemei ^{[9
]}

Liu, Renyi ^{[9
]}

Gong, Zhizhong ^{[8
]}

Zhu, Jian-Kang ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, Beijing 100864, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, Shanghai Inst Biol Sci, Beijing 100864, Peoples R China

[3] Purdue Univ, Dept Hort & Landscape Architecture, W Lafayette, IN 47906 USA

[4] Huazhong Agr Univ, Coll Plant Sci & Technol, Wuhan, Peoples R China

[5] Shanghai Agrobiol Gene Ctr, Shanghai 201106, Peoples R China

[6] Univ Texas MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA

[7] Nanyang Normal Univ, China UK NYNU RRes Joint Lab Insect Biol, Henan, Peoples R China

[8] China Agr Univ, Coll Biol Sci, State Key Lab Plant Physiol & Biochem, Beijing 100193, Peoples R China

[9] Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA

[10] Loma Linda Univ, Sch Med, Dept Biochem, Loma Linda, CA 92350 USA

[11] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA

来源：

SCIENCE | 2012年 / 336卷 / 6087期

基金：

美国国家卫生研究院;

关键词：

METHYLATION PATTERNS; GLYCOSYLASE/LYASE; TRIMETHYLATION; GENOME; PLANTS; ROS1;

D O I：

10.1126/science.1219416

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active DNA demethylation is regulated and its relationship with histone modification patterns are unclear. Here, we report the discovery of IDM1, a regulator of DNA demethylation in Arabidopsis. IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 and related 5-methylcytosine DNA glycosylases. IDM1 binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and acetylates H3 to create a chromatin environment permissible for 5-methylcytosine DNA glycosylases to function. Our study reveals how some genes are indicated by multiple epigenetic marks for active DNA demethylation and protection from silencing.

引用

页码：1445 / 1448

页数：4

共 10 条

[1] ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase [J].