Efficient enantioselective total synthesis of arabino-phytosphingosine

被引：11

作者：

Jung, DY ^{[1
]}

Kang, S ^{[1
]}

Chang, SB ^{[1
]}

Kim, YH ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Ctr Mol Design & Synth, Taejon 305701, South Korea

来源：

SYNLETT | 2005年 / 14期

关键词：

amino alcohol; enantioselective synthesis; total synthesis; sphingolipids; Claisen rearrangement;

D O I：

10.1055/s-2005-872242

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective total synthesis of arabino-phytosphingosine has been achieved in 8 steps employing Claisen rearrangement and Fleming-Tamao oxidation as key steps. Installation of all chiral centers present in arabino-phytosphingosine was achieved through the use of asymmetric catalysis. This synthesis provides one of the most efficient routes to prepare 2-amino- 1,3,4-triol moiety.

引用

页码：2183 / 2186

页数：4

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