Synthesis and mass spectrometry analysis of oligonucleotides bearing 5-formyl-2'-deoxyuridine in their structure

被引:18
作者
Berthod, T
Petillot, Y
Guy, A
Cadet, J
Forest, E
Molko, D
机构
[1] CEA GRENOBLE,LES ACIDES NUCL,SCIB,DEPT RECH FONDAMENTALE MAT CONDENSEE,F-38054 GRENOBLE 9,FRANCE
[2] CEA,CNRS,INST BIOL STRUCT,LAB SPECTROMET MASSE PROT,F-38027 GRENOBLE 1,FRANCE
来源
NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 7-8期
关键词
D O I
10.1080/07328319608002430
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two oligonucleotides containing FdU (1) have been synthesized. The use of the ''Pac-amidites'' for the natural nucleosides has allowed the incorporation of the oxidized thymine residue without protection of the aldehydic function. The oligonucleotide composition was confirmed by enzymatic digestion and electrospray mass spectrometry.
引用
收藏
页码:1287 / 1305
页数:19
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