CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig

被引：17

作者：

Vacca, C

Fallarino, F

Perruccio, K

Orabona, C

Bianchi, R

Gizzi, S

Velardi, A

Fioretti, MC

Puccetti, P

Grohmann, U

机构：

[1] Univ Perugia, Dept Expt Med & Biochem Sci, I-06126 Perugia, Italy

[2] Univ Perugia, Dept Clin & Expt Med, I-06126 Perugia, Italy

来源：

MICROBES AND INFECTION | 2005年 / 7卷 / 7-8期

关键词：

CTLA-4-Ig; human dendritic cells; tolerance; CD40L;

D O I：

10.1016/j.micinf.2005.03.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The synthetic immunomodulator cytotoxic T lymphocyte antigen 4-Ig (CTLA-4-Ig) initiates effects in human monocyte-derived dendritic cells (DC) that rely on immunosuppressive tryptophan catabolism. However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4. (c) 2005 Elsevier SAS. All rights reserved.

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收藏

页码：1040 / 1048

页数：9

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