When ligand becomes receptor -: tolerance via B7 signaling on DCs

被引：91

作者：

Finger, EB ^{[1
]}

Bluestone, JA ^{[1
]}

机构：

[1] Univ Calif San Francisco, Ctr Diabet, Sch Med, San Francisco, CA 94143 USA

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 11期

关键词：

D O I：

10.1038/ni1102-1056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CTLA-4-Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.

引用

页码：1056 / 1057

页数：2

共 13 条

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