Five novel oligostilbenes from the roots of Caragana sinica

被引:89
作者
Luo, HF [1 ]
Zhang, LP [1 ]
Hu, CQ [1 ]
机构
[1] Fudan Univ, Sch Pharm, Dept Chem Nat Drugs, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
Caragana sinica; leguminosae; caraphenol A; B; C; (+)-isoampelopsin F; (-)-ampelopsin F; oligostilbene; resveratrol; trimer; dimer;
D O I
10.1016/S0040-4020(01)00427-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
One novel resveratrol trimer, caraphenol A (1), and four novel resveratrol dimers, (+)-isoampelopsin F (2), caraphenol B (3), C (4), (-)-ampelopsin F (5) were isolated from the roots of C. sinica. Their structures and stereochemistry were elucidated by means of spectroscopic evidence, especially HMBC and NOE experiments. The pharmacological activities in anti-HIV of all compounds and stimulation of osteoblast growth tests of the EtOAc extract of the roots of C. sinica have been determined. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4849 / 4854
页数:6
相关论文
共 16 条
  • [1] HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato
    Dai, JR
    Hallock, YF
    Cardellina, JH
    Boyd, MR
    [J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (03): : 351 - 353
  • [2] THE EFFECTS OF RECOMBINANT HUMAN INTERLEUKIN-1-BETA ON CELLULAR PROLIFERATION AND THE PRODUCTION OF PROSTAGLANDIN-E2, PLASMINOGEN-ACTIVATOR, OSTEOCALCIN AND ALKALINE-PHOSPHATASE BY OSTEOBLAST-LIKE CELLS DERIVED FROM HUMAN-BONE
    EVANS, DB
    BUNNING, RAD
    RUSSELL, RGG
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 166 (01) : 208 - 216
  • [3] OSTEOPOROSIS AND DECLINE OF GONADAL-FUNCTION IN THE ELDERLY MALE
    FORESTA, C
    RUZZA, G
    MIONI, R
    GUARNERI, G
    GRIBALDO, R
    MENEGHELLO, A
    MASTROGIACOMO, I
    [J]. HORMONE RESEARCH, 1984, 19 (01) : 18 - 22
  • [4] (+)-ALPHA-VINIFERIN, AN ANTIINFLAMMATORY COMPOUND FROM CARAGANA-CHAMLAGU ROOT
    KITANAKA, S
    IKEZAWA, T
    YASUKAWA, K
    YAMANOUCHI, S
    TAKIDO, M
    SUNG, HK
    KIM, IH
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (02) : 432 - 435
  • [5] Kitanaka S, 1996, CHEM PHARM BULL, V44, P565, DOI 10.1248/cpb.44.565
  • [6] NATURALLY-OCCURRING PROTEIN-KINASE-C INHIBITORS .2. ISOLATION OF OLIGOMERIC STILBENES FROM CARAGANA-SINICA
    KULANTHAIVEL, P
    JANZEN, WP
    BALLAS, LM
    JIANG, JB
    HU, CQ
    DARGES, JW
    SELDIN, JC
    COFIELD, DJ
    ADAMS, LM
    [J]. PLANTA MEDICA, 1995, 61 (01) : 41 - 44
  • [7] α-viniferin:: A prostaglandin H2 synthase inhibitor from root of Carex humilis
    Lee, SH
    Shin, NH
    Kang, SH
    Park, JS
    Chung, SR
    Min, KR
    Kim, Y
    [J]. PLANTA MEDICA, 1998, 64 (03) : 204 - 207
  • [8] Luo H.F., 2000, J CHIN PHARM SCI, V9, P162
  • [9] Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives
    Ohyama, M
    Tanaka, T
    Ito, T
    Iinuma, M
    Bastow, KF
    Lee, KH
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (20) : 3057 - 3060
  • [10] POWERFUL HEPATOPROTECTIVE AND HEPATOTOXIC PLANT OLIGOSTILBENES, ISOLATED FROM THE ORIENTAL MEDICINAL PLANT VITIS-COIGNETIAE (VITACEAE)
    OSHIMA, Y
    NAMAO, K
    KAMIJOU, A
    MATSUOKA, S
    NAKANO, M
    TERAO, K
    OHIZUMI, Y
    [J]. EXPERIENTIA, 1995, 51 (01): : 63 - 66