Molecular reactions of protein phosphatases - Insights from structure and chemistry

被引：188

作者：

Jackson, MD ^{[1
]}

Denu, JM ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Biochem & Mol Biol, Portland, OR 97201 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000247e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The molecular reactions of protein phosphatases were studied. The last and rate-limiting step in the reaction involved dissociation of phosphate from the metal centre to regenerate the active enzyme. The results showed that the sequence identity and quaternary structure of protein tyrosine phosphatases varied from various family of the proteins.

引用

页码：2313 / 2340

页数：28

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