Molecular reactions of protein phosphatases - Insights from structure and chemistry

被引：188

作者：

Jackson, MD ^{[1
]}

Denu, JM ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Biochem & Mol Biol, Portland, OR 97201 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000247e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The molecular reactions of protein phosphatases were studied. The last and rate-limiting step in the reaction involved dissociation of phosphate from the metal centre to regenerate the active enzyme. The results showed that the sequence identity and quaternary structure of protein tyrosine phosphatases varied from various family of the proteins.

引用

页码：2313 / 2340

页数：28

共 265 条

[51] Protein tyrosine phosphatases: mechanisms of catalysis and regulation [J].

Denu, JM ;

Dixon, JE .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (05) :633-641

[52] LIGAND-MEDIATED NEGATIVE REGULATION OF A CHIMERIC TRANSMEMBRANE RECEPTOR TYROSINE PHOSPHATASE [J].

DESAI, DM ;

SAP, J ;

SCHLESSINGER, J ;

WEISS, A .

CELL, 1993, 73 (03) :541-554

[53] THE CATALYTIC ACTIVITY OF THE CD45 MEMBRANE-PROXIMAL PHOSPHATASE DOMAIN IS REQUIRED FOR TCR SIGNALING AND REGULATION [J].

DESAI, DM ;

SAP, J ;

SILVENNOINEN, O ;

SCHLESSINGER, J ;

WEISS, A .

EMBO JOURNAL, 1994, 13 (17) :4002-4010

[54] THE CDC25 PROTEIN CONTAINS AN INTRINSIC PHOSPHATASE-ACTIVITY [J].

DUNPHY, WG ;

KUMAGAI, A .

CELL, 1991, 67 (01) :189-196

[55] Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2 [J].

Eck, MJ ;

Pluskey, S ;

Trub, T ;

Harrison, SC ;

Shoelson, SE .

NATURE, 1996, 379 (6562) :277-280

[56]

Eckstein JW, 1996, PROTEIN SCI, V5, P5

[57] CRYSTAL-STRUCTURE OF THE CATALYTIC SUBUNIT OF HUMAN PROTEIN PHOSPHATASE-1 AND ITS COMPLEX WITH TUNGSTATE [J].

EGLOFF, MP ;

COHEN, PTW ;

REINEMER, P ;

BARFORD, D .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 254 (05) :942-959

[58] Novel application of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole to identify cysteine sulfenic acid in the AhpC component of alkyl hydroperoxide reductase [J].

Ellis, HR ;

Poole, LB .

BIOCHEMISTRY, 1997, 36 (48) :15013-15018

[59] Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: Structural insights into MKP-3 activation by ERK2 [J].

Farooq, A ;

Chaturvedi, G ;

Mujtaba, S ;

Plotnikova, O ;

Zeng, L ;

Dhalluin, C ;

Ashton, R ;

Zhou, MM .

MOLECULAR CELL, 2001, 7 (02) :387-399

[60] The x-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate - Mechanistic implications [J].

Fauman, EB ;

Yuvaniyama, C ;

Schubert, HL ;

Stuckey, JA ;

Saper, MA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18780-18788

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