Molecular reactions of protein phosphatases - Insights from structure and chemistry

被引：188

作者：

Jackson, MD ^{[1
]}

Denu, JM ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Biochem & Mol Biol, Portland, OR 97201 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000247e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The molecular reactions of protein phosphatases were studied. The last and rate-limiting step in the reaction involved dissociation of phosphate from the metal centre to regenerate the active enzyme. The results showed that the sequence identity and quaternary structure of protein tyrosine phosphatases varied from various family of the proteins.

引用

页码：2313 / 2340

页数：28

共 265 条

[31] CHARACTERIZATION OF PHOSPHOTYROSYL-PROTEIN PHOSPHATASE-ACTIVITY ASSOCIATED WITH CALCINEURIN [J].

CHERNOFF, J ;

SELLS, MA ;

LI, HC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 121 (01) :141-148

[32] A MAJOR PHOSPHOTYROSYL-PROTEIN PHOSPHATASE FROM BOVINE HEART IS ASSOCIATED WITH A LOW-MOLECULAR-WEIGHT ACID-PHOSPHATASE [J].

CHERNOFF, J ;

LI, HC .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 240 (01) :135-145

[33] ISOLATION AND STRUCTURAL ELUCIDATION OF A NOVEL PHOSPHOCYSTEINE INTERMEDIATE IN THE LAR PROTEIN TYROSINE PHOSPHATASE ENZYMATIC PATHWAY [J].

CHO, HJ ;

KRISHNARAJ, R ;

KITAS, E ;

BANNWARTH, W ;

WALSH, CT ;

ANDERSON, KS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (18) :7296-7298

[34] THE ROLE OF CYS12, CYS17 AND ARG18 IN THE CATALYTIC MECHANISM OF LOW-MR CYTOSOLIC PHOSPHOTYROSINE PROTEIN PHOSPHATASE [J].

CIRRI, P ;

CHIARUGI, P ;

CAMICI, G ;

MANAO, G ;

RAUGEI, G ;

CAPPUGI, G ;

RAMPONI, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 214 (03) :647-657

[35] Mechanisms of phosphoryl and acyl transfer [J].

Cleland, WW ;

Hengge, AC .

FASEB JOURNAL, 1995, 9 (15) :1585-1594

[36] SECONDARY O-18 ISOTOPE EFFECTS AS A TOOL FOR STUDYING REACTIONS OF PHOSPHATE MONOESTERS, DIESTERS, AND TRIESTERS [J].

CLELAND, WW .

FASEB JOURNAL, 1990, 4 (11) :2899-2905

[37] THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES [J].

COHEN, P .

ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :453-508

[38] AN IMPROVED PROCEDURE FOR IDENTIFYING AND QUANTITATING PROTEIN PHOSPHATASES IN MAMMALIAN-TISSUES [J].

COHEN, P ;

KLUMPP, S ;

SCHELLING, DL .

FEBS LETTERS, 1989, 250 (02) :596-600

[39]

COHEN P, 1989, J BIOL CHEM, V264, P21435

[40] Novel protein serine/threonine phosphatases: Variety is the spice of life [J].

Cohen, PTW .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (07) :245-251

← 1 2 3 4 5 6 7 8 9 10 →