Cadherin function: Breaking the barrier

被引：25

作者：

Ishii, K

Green, KJ

机构：

[1] Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA

[2] Northwestern Univ, Sch Med, Dept Dermatol, Chicago, IL 60611 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-9822(01)00346-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three desmoglein isoforms collaborate with desmocollins to build the adhesive core of desmosomes. A recent study has shown that altering the ratio of desmoglein isoforms influences epidermal barrier function, suggesting distinct roles for these cadherins that extend beyond adhesion.

引用

收藏

页码：R569 / R572

页数：4

相关论文

共 29 条

[1] Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation [J].

Allen, E ;

Yu, QC ;

Fuchs, E .

JOURNAL OF CELL BIOLOGY, 1996, 133 (06) :1367-1382

[2] AUTOANTIBODIES AGAINST A NOVEL EPITHELIAL CADHERIN IN PEMPHIGUS-VULGARIS, A DISEASE OF CELL-ADHESION [J].

AMAGAI, M ;

KLAUSKOVTUN, V ;

STANLEY, JR .

CELL, 1991, 67 (05) :869-877

[3] ANTIGEN-SPECIFIC IMMUNOADSORPTION OF PATHOGENIC AUTOANTIBODIES IN PEMPHIGUS FOLIACEUS [J].

AMAGAI, M ;

HASHIMOTO, T ;

GREEN, KJ ;

SHIMIZU, N ;

NISHIKAWA, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (06) :895-901

[4] Pemphigus vulgaris antigen (Desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients [J].

Amagai, M ;

Koch, PJ ;

Nishikawa, T ;

Stanley, JR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (02) :351-355

[5]

Angst BD, 2001, J CELL SCI, V114, P629

[6] Plakoglobin suppresses epithelial proliferation and hair growth in vivo. [J].

Charpentier, E ;

Lavker, RM ;

Acquista, E ;

Cowin, P .

JOURNAL OF CELL BIOLOGY, 2000, 149 (02) :503-519

[7] Stratum corneum tryptic enzyme in normal epidermis: A missing link in the desquamation process? [J].

Ekholm, IE ;

Brattsand, M ;

Egelrud, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 114 (01) :56-63

[8] Desmoglein isoform distribution affects stratum corneum structure and function [J].

Elias, PM ;

Matsuyoshi, N ;

Wu, H ;

Lin, CY ;

Wang, ZH ;

Brown, BE ;

Stanley, JR .

JOURNAL OF CELL BIOLOGY, 2001, 153 (02) :243-249

[9] Are desmosomes more than tethers for intermediate filaments? [J].

Green, KJ ;

Gaudry, CA .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (03) :208-216

[10]

Haake A, 1999, FITZPATRICKS DERMATO, V5th, P70