Cadherin function: Breaking the barrier

被引：25

作者：

Ishii, K

Green, KJ

机构：

[1] Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA

[2] Northwestern Univ, Sch Med, Dept Dermatol, Chicago, IL 60611 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-9822(01)00346-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three desmoglein isoforms collaborate with desmocollins to build the adhesive core of desmosomes. A recent study has shown that altering the ratio of desmoglein isoforms influences epidermal barrier function, suggesting distinct roles for these cadherins that extend beyond adhesion.

引用

收藏

页码：R569 / R572

页数：4

相关论文

共 29 条

[11] Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2 [J].

Hakimelahi, S ;

Parker, HR ;

Gilchrist, AJ ;

Barry, M ;

Li, Z ;

Bleackley, RC ;

Pasdar, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (15) :10905-10911

[12] Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis [J].

Hazan, RB ;

Phillips, GR ;

Qiao, RF ;

Norton, L ;

Aaronson, SA .

JOURNAL OF CELL BIOLOGY, 2000, 148 (04) :779-790

[13]

ISHII K, 2001, IN PRESS J INVEST DE

[14] Targeted disruption of the pemphigus vulgaris antigen (Desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris [J].

Koch, PJ ;

Mahoney, MG ;

Ishikawa, H ;

Pulkkinen, L ;

Uitto, J ;

Shultz, L ;

Murphy, GF ;

WhitakerMenezes, D ;

Stanley, JR .

JOURNAL OF CELL BIOLOGY, 1997, 137 (05) :1091-1102

[15]

Kolligs FT, 2000, GENE DEV, V14, P1319

[16]

Llorens A, 1998, LAB INVEST, V78, P1131

[17] EVIDENCE THAT CELL SHEDDING FROM PLANTAR STRATUM-CORNEUM INVITRO INVOLVES ENDOGENOUS PROTEOLYSIS OF THE DESMOSOMAL PROTEIN DESMOGLEIN-I [J].

LUNDSTROM, A ;

EGELRUD, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (02) :216-220

[18]

Luo J, 1999, CANCER RES, V59, P3552

[19]

Marcozzi C, 1998, J CELL SCI, V111, P495

[20] Bricks and mortar of the epidermal barrier [J].

Nemes, Z ;

Steinert, PM .

EXPERIMENTAL AND MOLECULAR MEDICINE, 1999, 31 (01) :5-19