Headspace single-drop microextraction with in-drop derivatization for aldehyde analysis

被引：48

作者：

Deng, CH ^{[1
]}

Yao, N ^{[1
]}

Li, N ^{[1
]}

Zhang, XM ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

JOURNAL OF SEPARATION SCIENCE | 2005年 / 28卷 / 17期

关键词：

aldehydes; derivatization; gas chromatography-mass spectrometry; headspace single-drop microextraction with in-drop derivatization; solvent microextraction;

D O I：

10.1002/jssc.200500085

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new technique, headspace single-drop microextraction (HS-SDME) with in-drop derivatization, was developed. Its feasibility was demonstrated by analysis of the model compounds, aldehydes in water. A hanging microliter drop of solvent containing the derivatization agent of O-2,3,4,5,6-(pentaflurobenzyl) hydroxylamine hydrochloride (PFBHA) was shown to be an excellent extraction, concentration, and derivatization medium for headspace analysis of aldehydes by GC-MS. Using the microdrop solvent with PFBHA, acetaldehyde, propanal, butanal, hexanal, and heptanal in water were headspace extracted and simultaneously derivatized. The formed oximes in the microdrop were analyzed by GC-MS. HS-SIDME and in-drop derivatization parameters (extraction solvent, extraction temperature, extraction time, stirring rate microdrop volume, and the headspace volume) and the method validations (linearity, precision, detection limit, and recovery) were studied. Compared to liquid-liquid extraction and solid-phase microextraction, HS-SIDME with in-drop derivatization is a simple, rapid, convenient, and inexpensive sample technique.

引用

页码：2301 / 2305

页数：5

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