Silica-coated nanocomposites of magnetic nanoparticles and quantum dots

被引:774
作者
Yi, DK
Selvan, ST
Lee, SS
Papaefthymiou, GC
Kundaliya, D
Ying, JY
机构
[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
[2] Villanova Univ, Dept Phys, Villanova, PA 19085 USA
[3] Univ Maryland, Dept Phys, Ctr Superconduct Res, College Pk, MD 20742 USA
关键词
D O I
10.1021/ja0428863
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Quantum dots (QDs) and magnetic nanoparticles (MPs) are of interest for biological imaging, drug targeting, and bioconjugation because of their unique optoelectronic and magnetic properties, respectively. To provide for water solubility and biocompatibility, QDs and MPs were encapsulated within a silica shell using a reverse microemulsion synthesis. The resulting SiO2/MP-QD nanocomposite particles present a unique combination of magnetic and optical properties. Their nonporous silica shell allows them to be surface modified for bioconjugation in various biomedical applications. Copyright © 2005 American Chemical Society.
引用
收藏
页码:4990 / 4991
页数:2
相关论文
共 26 条
[1]   THERMAL FLUCTUATIONS OF A SINGLE-DOMAIN PARTICLE [J].
BROWN, WF .
PHYSICAL REVIEW, 1963, 130 (05) :1677-+
[2]   Semiconductor nanocrystals as fluorescent biological labels [J].
Bruchez, M ;
Moronne, M ;
Gin, P ;
Weiss, S ;
Alivisatos, AP .
SCIENCE, 1998, 281 (5385) :2013-2016
[3]   Luminescent quantum dots for multiplexed biological detection and imaging [J].
Chan, WCW ;
Maxwell, DJ ;
Gao, XH ;
Bailey, RE ;
Han, MY ;
Nie, SM .
CURRENT OPINION IN BIOTECHNOLOGY, 2002, 13 (01) :40-46
[4]  
COLVIN VL, 1994, NATURE, V370, P354, DOI 10.1038/370354a0
[5]   Quantum dot molecules assembled with genetically engineered proteins [J].
Ding, SY ;
Jones, M ;
Tucker, MP ;
Nedeljkovic, JM ;
Wall, J ;
Simon, MN ;
Rumbles, G ;
Himmel, ME .
NANO LETTERS, 2003, 3 (11) :1581-1585
[6]   Photoluminescence spectroscopy of single CdSe nanocrystallite quantum dots [J].
Empedocles, SA ;
Norris, DJ ;
Bawendi, MG .
PHYSICAL REVIEW LETTERS, 1996, 77 (18) :3873-3876
[7]   Fluorescence quantum yield of rhodamine 6G in ethanol as a function of concentration using thermal lens spectrometry [J].
Fischer, M ;
Georges, J .
CHEMICAL PHYSICS LETTERS, 1996, 260 (1-2) :115-118
[8]   Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots [J].
Gerion, D ;
Pinaud, F ;
Williams, SC ;
Parak, WJ ;
Zanchet, D ;
Weiss, S ;
Alivisatos, AP .
JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (37) :8861-8871
[9]   Facile one-pot synthesis of bifunctional heterodimers of nanoparticles: A conjugate of quantum dot and magnetic nanoparticles [J].
Gu, HW ;
Zheng, RK ;
Zhang, XX ;
Xu, B .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (18) :5664-5665
[10]   Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules [J].
Han, MY ;
Gao, XH ;
Su, JZ ;
Nie, S .
NATURE BIOTECHNOLOGY, 2001, 19 (07) :631-635