Lupane triterpenes and derivatives with antiviral activity

被引：107

作者：

Baltina, LA

Flekhter, OB

Nigmatullina, LR

Boreko, EI

Pavlova, NI

Nikolaeva, SN

Savinova, OV

Tolstikova, GA

机构：

[1] RAS, Ufa Res Ctr, Inst Organ Chem, Ufa 450054, Russia

[2] Belorussian Epidemiol & Microbiol Res Inst, Minsk 220050, BELARUS

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1016/S0960-894X(03)00714-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Betulin and betulinic acid have been modified at the C-3 and C-28 positions and the antiviral activity of derivatives has been evaluated in vitro. It was found that simple modifications of the parent structure of lupane triterpenes produced highly effective agents against influenza A and herpes simplex type 1 viruses. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3549 / 3552

页数：4

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